Vitamin D

Matthew Capowski

Matthew Capowski

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Staff member
Herbalist
This is going to be a long thread. Vitamin D is a wonderous molecule with many benefits.

Peter Bergman, Anna-Carin Norlin, Susanne Hansen, Rokeya Sultana Rekha, Birgitta Agerberth, Linda Björkhem-Bergman, Lena Ekström, Jonatan D Lindh, Jan Andersson. Vitamin D3 supplementation in patients with frequent respiratory tract infections: a randomised and double-blind intervention study. BMJ Open, 2012; 2: 6 e001663 DOI: 10.1136/bmjopen-2012-001663

Mayo Clinic. "Vitamin D toxicity rare in people who take supplements, researchers report." ScienceDaily. ScienceDaily, 30 April 2015. www.sciencedaily.com/releases/2015/04/150430134852.htm

Americans have low vitamin D levels, research shows, and as a result, vitamin D supplement use has climbed in recent years. Vitamin D has been shown to boost bone health and it may play a role in preventing diabetes, cancer, cardiovascular disease and other illnesses. In light of the increased use of vitamin D supplements, researchers set out to learn more about the health of those with high vitamin D levels. They found that toxic levels are actually rare.
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Effects of vitamin D supplementation on intestinal permeability, cathelicidin and disease markers in Crohn’s disease: Results from a randomised double-blind placebo-controlled study [PDF file of study]

The above study finds that 2000IU/day for 3 months helped reduce both inflammation in Chrohn's disease and reduced intestinal permeability.

Vitamin D Status and Rates of Cognitive Decline in a Multiethnic Cohort of Older Adults:
http://archneur.jamanetwork.com/article.aspx?articleid=2436596

Low VitD status was associated with accelerated decline in cognitive function domains in ethnically diverse older adults, including African American and Hispanic individuals who exhibited a high prevalence of VitD insufficiency or deficiency. It remains to be determined whether VitD supplementation slows cognitive decline.
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Efficacy and safety of vitamin D3 intake exceeding the lowest observed adverse effect level: https://www.ncbi.nlm.nih.gov/pubmed/11157326

A letter to the editor about preventing respiratory infections that discusses the virtues of Vitamin D: https://www.bmj.com/content/368/bmj.m810/rr-11

Large, single-dose, oral vitamin D supplementation in adult populations: a systematic review. https://www.ncbi.nlm.nih.gov/pubmed/24246341

Safety of High-Dose Vitamin D Supplementation: Secondary Analysis of a Randomized Controlled Trial https://academic.oup.com/jcem/article-abstract/105/4/dgz212/5634116?redirectedFrom=fulltext

Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths https://www.mdpi.com/2072-6643/12/4/988/htm
 
https://www.tiktok.com/video/7155116916670090502

How true is this? I tried to look into this and found:

"Thus, vitamin D at physiological doses may enhance magnesium absorption in non previously vitamin D-depleted pigs fed diets with abundant magnesium. This nutritional situation may help explain the predominant bone-resorbing effect of vitamin D supplementation."

pubmed.ncbi.nlm.nih.gov

Effects of dietary vitamin D on magnesium absorption and bone mineral contents in pigs on normal magnesium intakes - PubMed

The effects of three dietary levels of vitamin D (500, 1500 and 3000 IU/kg diet) on magnesium metabolism and on some bone parameters related to bone mineralization were studied in vitamin D-repleted pigs fed normal magnesium intakes (0.2 per cent) for two months. Apparent absorption and...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

And then there is some other research about magnesium potentially being necessary to make vitamin D bioavailable.

This one study says "and taking large doses of vitamin D can induce severe depletion of Mg" but I don't see more details:

pubmed.ncbi.nlm.nih.gov

Magnesium Supplementation in Vitamin D Deficiency - PubMed

Vitamin D screening assay is readily available, but the reported lower limit of the normal range is totally inadequate for disease prevention. Based on the epidemiologic studies, ∼75% of all adults worldwide have serum 25(OH)D levels of <30 ng/mL. Because of the recent increase in global awarenes …
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

So at what levels of vitamin D intake do we have to worry about this?
 
Paul Bergner in his excellent book on minerals states "High intakes of calcium, protein, vitamin D, and alcohol all increase the magnesium requirement." So I think it's fair to say that there's truth to taking into consideration magnesium when doing high doses of vitamin D. Where exactly to draw the lines, though, I'm unsure.
 
Vitamin D Supplementation: To D or Not to D?


From the conclusion:

The health benefits of adequate vitamin D intake should not be ignored. For patients who are getting sufficient vitamin D without a supplement, a supplement may not be necessary. For patients who are obviously not getting sufficient vitamin D through natural means, it would be reasonable in many cases to just take a supplement without laboratory testing. For those who are unsure about the adequacy of their vitamin D intake or are at high risk for complications of vitamin D deficiency, it may be worthwhile to check a level to guide treatment. In other words, clinicians should assess an individual patient’s risk for vitamin D deficiency (eg, weight, race, time outdoors, location, comorbid conditions, medications). If the patient’s risk of vitamin D deficiency is low, testing or supplementation is unnecessary. If a patient is at risk for vitamin D deficiency (which is a large portion of the population), there should be shared decision-making between clinician and patient about testing vs empirical supplementation.
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