This thread will be used to discuss St. John's Wort.
HYPERICUM, DRUG INTERACTIONS, AND LIVER EFFECTS by Paul Bergner https://medherb.com/hypericum-drug-herb.html
Antiviral Activity Against Infectious Bronchitis Virus and Bioactive Components of Hypericum perforatum L. https://www.frontiersin.org/articles/10.3389/fphar.2019.01272/full
Our study provides, for the first time, clear evidence that the extract of H. perforatum, containing hyperoside, quercitrin, quercetin, pseudohypericin, and hypericin, possess anti-IBV activities. Furthermore, its anti-IBV effect may be associated with reduced mRNA expression levels of the pro-inflammatory cytokines IL-6, TNF-α by NF-κB signaling pathway, and related to up-regulate mRNA expression levels of type I interferon through the MDA5 signaling pathway, and could be useful for the development of new antiviral agents. However, further studies are required to elucidate its detail mechanism of action.
Anti-influenza A virus effect of Hypericum perforatum L. extract https://link.springer.com/article/10.1007/s12250-009-2983-x
The minimum effective dose of HPE in these studies was 31.25 mg/kg/day, which was administered twice daily for 5 d beginning 4 h prior to virus exposure. Below a dosage of 2000 mg/kg/day, almost all treated mice survived, which suggests that HPE is of low toxicity. Ribavirin’s minimum effective dose was 40 mg/kg/day with the LD50 determined to be 200 mg/kg/day. Delay of the initiation of either HPE or ribavirin therapy, using approximately 1/3 LD50 dose each time, could still be protective as late as 48 h after exposure to the IAV. While both agents appeared to have similar efficacy against IAV infections, HPE was considered to be less toxic and may warrant further evaluation as a possible therapy for influenza.
Medical Attributes of St. John’s Wort (Hypericum perforatum) https://www.ncbi.nlm.nih.gov/books/NBK92750/
St. John’s Wort: A Review by Dr. Christopher Hobbs https://www.christopherhobbs.com/library/articles-on-herbs-and-health/st-johns-wort-a-review/
St. John’s Wort: Ancient Herbal Protector by Dr. Christopher Hobbs https://www.christopherhobbs.com/li...ealth/st-johns-wort-ancient-herbal-protector/
St. John's Wort: https://www.nccih.nih.gov/health/st-johns-wort
HYPERICUM, DRUG INTERACTIONS, AND LIVER EFFECTS by Paul Bergner https://medherb.com/hypericum-drug-herb.html
Antiviral Activity Against Infectious Bronchitis Virus and Bioactive Components of Hypericum perforatum L. https://www.frontiersin.org/articles/10.3389/fphar.2019.01272/full
Our study provides, for the first time, clear evidence that the extract of H. perforatum, containing hyperoside, quercitrin, quercetin, pseudohypericin, and hypericin, possess anti-IBV activities. Furthermore, its anti-IBV effect may be associated with reduced mRNA expression levels of the pro-inflammatory cytokines IL-6, TNF-α by NF-κB signaling pathway, and related to up-regulate mRNA expression levels of type I interferon through the MDA5 signaling pathway, and could be useful for the development of new antiviral agents. However, further studies are required to elucidate its detail mechanism of action.
Anti-influenza A virus effect of Hypericum perforatum L. extract https://link.springer.com/article/10.1007/s12250-009-2983-x
The minimum effective dose of HPE in these studies was 31.25 mg/kg/day, which was administered twice daily for 5 d beginning 4 h prior to virus exposure. Below a dosage of 2000 mg/kg/day, almost all treated mice survived, which suggests that HPE is of low toxicity. Ribavirin’s minimum effective dose was 40 mg/kg/day with the LD50 determined to be 200 mg/kg/day. Delay of the initiation of either HPE or ribavirin therapy, using approximately 1/3 LD50 dose each time, could still be protective as late as 48 h after exposure to the IAV. While both agents appeared to have similar efficacy against IAV infections, HPE was considered to be less toxic and may warrant further evaluation as a possible therapy for influenza.
Medical Attributes of St. John’s Wort (Hypericum perforatum) https://www.ncbi.nlm.nih.gov/books/NBK92750/
St. John’s Wort: A Review by Dr. Christopher Hobbs https://www.christopherhobbs.com/library/articles-on-herbs-and-health/st-johns-wort-a-review/
St. John’s Wort: Ancient Herbal Protector by Dr. Christopher Hobbs https://www.christopherhobbs.com/li...ealth/st-johns-wort-ancient-herbal-protector/
St. John's Wort: https://www.nccih.nih.gov/health/st-johns-wort