Metabolic Syndrome / Syndrome X / Insulin Resistance

Matthew Capowski

Staff member
This thread will be used to organize all information about metabolic syndrome.

For a concise overview of metabolic syndrome I will quote Todd Cadlecott from his article on Metabolic Syndrome:

It has been observed for a number of years that conditions such as adult onset diabetes, hypertension, elevated blood levels of cholesterol, elevated serum levels of low-density lipoproteins, obesity, and coronary heart disease are common disorders that often occur in one patient. Cardiologists originally described a condition, termed syndrome X, that identified patients with angina pectoris and positive stress-test ECG but with no evidence of stenoses of the coronary arteries. Further study revealed that these patients often have a decreased insulin-stimulated glucose uptake. In 1988 medical researcher Gerald Reaven postulated that these metabolic and cardiovascular disorders are a multifaceted syndrome characterized by insulin resistance with compensatory ncreased insulin secretion of the pancreas leading to elevated levels of insulin in the blood, or hyperinsulinemia.

Paul Bergner also has a brief article on Syndrome X titled Syndrome X Notes:

The Wild Rose Clinic has a Syndrome X Questionnaire that scores your risk for Syndrome X:

Sanjay Basu, Paula Yoffe, Nancy Hills, Robert H. Lustig. The Relationship of Sugar to Population-Level Diabetes Prevalence: An Econometric Analysis of Repeated Cross-Sectional Data. PLoS ONE, 2013; 8 (2): e57873 DOI: 10.1371/journal.pone.0057873

This issue:

Of the Journal of Medical Herbalism has an article in it titled "Herbs and insulin resistance" by Paul Bergner.

Interesting article about recent research suggesting that people with metabolic syndrome had lower vitamin E than expected:

Metabolic syndrome leads one in three Americans to need more vitamin E:

Vitamin D for metabolic syndrome:

I'm still trying to understand the significance of this: A microbial protein that alleviates metabolic syndrome

Insulin resistance begins in the liver? (Paid article unfortunately)

Effect of carbohydrate-restricted dietary interventions on LDL particle size and number in adults in the context of weight loss or weight maintenance: a systematic review and meta-analysis

"The available evidence indicates that dietary interventions restricted in carbohydrates increase LDL peak particle size and decrease the numbers of total and small LDL particles."

The Carbohydrate-Insulin Model of Obesity: Beyond ‘Calories In, Calories Out’
"A spate of recent reviews claim to refute the CIM, but these attacks are premised on a misunderstanding of physiological mechanisms, misinterpretation of metabolic studies and disregard for much supportive data."
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